The Hepato-Renal Effect of Graded Doses of a Glyphosate-Based Herbicide (Roundup) in Rat
 /  The Hepato-Renal Effect of Graded Doses of a Glyphosate-Based Herbicide (Roundup) in Rat

The Hepato-Renal Effect of Graded Doses of a Glyphosate-Based Herbicide (Roundup) in Rat

M. A. Adiakpoh* and M. O. Alegun

Abstract
Roundup, one of the most widely used glyphosate-based herbicides is classified as hazardous to the
environment. Its low persistence leads to repeated applications and consequently, large portions contaminate
soil and water bodies, causing harm to non-target species. The hepato-renal toxicity of graded doses (300, 400
and 600 mgKg-1body wt) of roundup on selected serum metabolites, enzymes and hematological parameters
was investigated in rats (Wistar strain; 207g± 6 g). Thirty–two male rats were divided into four groups; control
(n = 8) and test groups (n = 24), divided into 3 groups of eight rats each that received graded doses o f the
herbicide, respectively for 8 days. Hepatotoxicity was investigated by quantitative analysis of serum alanine
transaminase (ALT), alkaline phosphatase (ALP), total protein, albumin, globulin and cholesterol levels. Renal –
toxicity was determined by quantitative analysis of serum creatinine, urea, K+ and Na+ levels. Relative to the
control, there was significant (p<0.05) reduction in the activities of ALT and ALP while serum total protein,
albumin and globulin levels were significantly (p<0.05) elevated in the groups that received high doses of the
herbicide. Creatinine, urea, Na+ and hematocrit were significantly (p<0.05) elevated while K+, white blood
cell and lymphocyte were significantly (p<0.05) reduced in the groups that received the high doses of the
herbicide, relative to the control. Histopathological studies revealed periportal steatosis and mild necrosis in
the liver and thickened alveolar septae filled with inflammatory cells in the lung tissues. This study shows that
high doses of roundup may be toxic to the hepatorenal tissues of rat.

 

Journal Article
PDF, 137.2 KB
Creative Commons LicenseCreative Commons license
Biological Sciences
Biochemistry
Roundup, hepato-renal, toxicity, histopathology, rat
Christian Bassey
12th April, 2018
13th April, 2018
http://oer.mciu.edu.ng/wp-content/uploads/2015/04/15-M.-O.-Alegun.pdf


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