Evaluation of the Therapeutic Efficacy of Antiretroviral Drugs used in the Clinical Management of HIV/ AIDS Infection
 /  Evaluation of the Therapeutic Efficacy of Antiretroviral Drugs used in the Clinical Management of HIV/ AIDS Infection

Evaluation of the Therapeutic Efficacy of Antiretroviral Drugs used in the Clinical Management of HIV/ AIDS Infection

Anochie P. I. et. al.

Abstract
The protease inhibitors are potent antiretroviral drugs because the protease activity is absolutely
essential for production of infectious viruses. The newest class of drugs is the fusion inhibitors that
blocks virus entry into cells. Persistent virus production is facilitated further by sub-inhibitory drug levels
in infected cells or by host immune failure. Therefore, pre-existing or newly produced drug resistant
mutants can emerge that have a selective advantage under drug pressure. These escape mutants
become dominant in the virus population and lead to viral rebound and therapy failure. This review
provides knowledge for improvement of antiretroviral drug administration programmes.

Journal Article
PDF, 188.4 KB
Creative Commons LicenseCreative Commons license
Biological Sciences
Microbiology
Evaluation; Therapeutic; Efficacy; Antiretroviral; Drugs; Management; HIV/AIDS; Infection
Christian Bassey
18th April, 2018
18th April, 2018
http://oer.mciu.edu.ng/wp-content/uploads/2015/04/Philip-anochie-5.pdf


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