A. E. Akpovona 1 and I. O. Onoagbe 2
This study investigated the effects of aqueous and ethanol extracts of Terminalia
macroptera stem bark (TMSB) in Wistar rats via white blood cell count and its differentials; erythrocytic
parameters (EP) [red blood cell count, haemoglobin, packed cell volume, mean corpuscular volume, mean
corpuscular haemoglobin and mean corpuscular haemoglobin concentration]; platelet count and plateletto-lymphocyte
ratio (PLR). Daily oral administration of extracts at low (50 and 200 mg/kg), mid (400 and
600 mg/kg) and high doses (1000 and 1200 mg/kg) were delivered to four female rats in six groups
respectively for 28 days while control group received distilled water. Thereafter, animals were sacrificed
and harvested blood analysed using automated systems. The results showed that high doses (1000 and
1200 mg/kg) of both extracts respectively caused granulocytic leukocytosis. However, only ethanol extract
(EE) induced lymphocytopenia (1000 mg/kg, p=0.005; 1200 mg/kg, p=0.013) while granulocytosis observed
with low doses had no corresponding increases in white blood cell counts. Aqueous extract (AE) had no
effect on EP whereas significant increases were observed in groups administered 50 – 400 mg/kg of EE.
PLR was 44.34 (± 6.58) in 1200 mg/kg aqueous extract dosed rats, significantly lower (p=0.01) than control
group [73.03 (±5.14)], but higher in rats dosed with EE at 1000 mg/kg [PLR=175.55 (± 3.84); p<0.001] and
1200 mg/kg [PLR=117.28 (±3.90); p=0.005] respectively. These findings revealed that TMSB(AE) possesses
immunoimpressive potential at high doses without significant erythropoietic effects while high doses of
TMSB(EE) exhibits possible induction of systemic inflammation inaddition to erythropoietic boost at low to
mid dose ranges.
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Terminalia macroptera, food intake, food to body weight conversion index.
12th April, 2018
13th April, 2018