CLINICAL MANAGEMENT OF HIV/AIDS INFECTION USING ANTIRETROVIRAL DRUGS IN A NIGERIAN ENDEMIC SETTING
 /  CLINICAL MANAGEMENT OF HIV/AIDS INFECTION USING ANTIRETROVIRAL DRUGS IN A NIGERIAN ENDEMIC SETTING

CLINICAL MANAGEMENT OF HIV/AIDS INFECTION USING ANTIRETROVIRAL DRUGS IN A NIGERIAN ENDEMIC SETTING

Anochie, P.I et. al.

Abstract
Current HIV/AIDS treatment strategies aim at maximal suppression of virus load
levels (the number of free virus particles in the blood plasma) over long periods.
Aside from inducing strong side effects, the long term effectiveness of HAART is
also limited by the evolution of drug-resistant variants. Even in patients with viral
load levels suppressed below detectable limits (50 copies/ml), ongoing viral
replication can be found in a variety of tissues and cell types. Persistent virus
production is facilitated by sub-inhibitory drug levels in infected cells or by host
immune failure. Therefore, pre-existing or newly produced drug resistant mutants can
emerge that have a selective advantage under drug pressure.
These mutants become dominant in the virus population and lead to viral rebound and
therapy failure. The protease inhibitors are potent antiviral drugs because the protease
activity is absolutely essential for production of infectious viruses. The newest class
of drugs is the fusion inhibitors that block virus entry into cells.

Journal Article
PDF, 295.5 KB
Creative Commons LicenseCreative Commons license
Biological Sciences
Microbiology
HIV/AIDS, Antiretroviral, HAART
Christian Bassey
18th April, 2018
18th April, 2018
http://oer.mciu.edu.ng/wp-content/uploads/2015/04/Philip-anochie-7.pdf


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